Precision Target
Approach
Microtubule cytoskeleton
A proven therapeutic target
Microtubules, consisting of alpha-beta tubulin hetero-dimers, play a fundamental role as dynamic filaments within cells. They serve as essential components of the cytoskeleton and form spindle fibers responsible for the segregation of chromosomes during cell division. Disrupting the functions of microtubules through the use of small molecule drugs, referred to as microtubule targeting agents (MTAs), is a proven strategy to tackle multiple diseases like cancer.
De-stabilising Drugs
Promote Microtubule Breakdown
Stabilising Drugs
Promote Microtubule Formation
Microtubule cytoskeleton of Eukaryotic pathogens
A promising therapeutic target
Through the course of their pathogenic evolution, eukaryotic pathogens have acquired remarkable modifications in the sequence, structure, and function, of their cytoskeleton, setting them apart from their host organisms. These unique characteristics make them a highly appealing target for targeted therapeutic interventions.
Toxoplasma gondii
Tachyzoites highlighting unique microtubules
Halting Pathogen Proliferation with Parabulins
A precision targeting approach
At ASTRA Therapeutics, we have pioneered ParaX , an innovative and efficient Pathogen-Specific Tubulin Drug Development Platform. Through ParaX , we generate species-specific tubulin drug leads known as Parabulins , which serve as the foundation for therapeutic solutions. With enhanced efficacy and efficiency, we are reshaping the landscape of targeted treatments, bringing us closer to effective interventions against eukaryotic pathogens.
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